Viral Shedding and Antibody Response in 37 Patients With Middle East Respiratory Syndrome Coronavirus Infection
Identifieur interne : 001517 ( Main/Exploration ); précédent : 001516; suivant : 001518Viral Shedding and Antibody Response in 37 Patients With Middle East Respiratory Syndrome Coronavirus Infection
Auteurs : Victor M. Corman [Allemagne] ; Ali M. Albarrak ; Ali Senosi Omrani ; Mohammed M. Albarrak ; Mohamed Elamin Farah ; Malak Almasri ; Doreen Muth [Allemagne] ; Andrea Sieberg ; Benjamin Meyer ; Abdullah M. Assiri ; Tabea Binger ; Katja Steinhagen [Allemagne] ; Erik Lattwein [Allemagne] ; Jaffar Al-Tawfiq ; Marcel A. Müller ; Christian Drosten [Allemagne] ; Ziad A. MemishSource :
- Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America [ 1058-4838 ] ; 2015.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Anticorps antiviraux (sang), Anticorps neutralisants (sang), Appareil respiratoire (virologie), Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification), Excrétion virale, Femelle, Fèces (virologie), Humains, Infections à coronavirus (immunologie), Infections à coronavirus (virologie), Jeune adulte, Mâle, Production d'anticorps, Sang (virologie), Sujet âgé, Sujet âgé de 80 ans ou plus, Urine (virologie).
- MESH :
- immunologie : Infections à coronavirus.
- isolement et purification : Coronavirus du syndrome respiratoire du Moyen-Orient.
- sang : Anticorps antiviraux, Anticorps neutralisants.
- virologie : Appareil respiratoire, Fèces, Infections à coronavirus, Sang, Urine.
- Adulte, Adulte d'âge moyen, Excrétion virale, Femelle, Humains, Jeune adulte, Mâle, Production d'anticorps, Sujet âgé, Sujet âgé de 80 ans ou plus.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Antibodies, Neutralizing (blood), Antibodies, Viral (blood), Antibody Formation, Blood (virology), Coronavirus Infections (immunology), Coronavirus Infections (virology), Feces (virology), Female, Humans, Male, Middle Aged, Middle East Respiratory Syndrome Coronavirus (isolation & purification), Respiratory System (virology), Urine (virology), Virus Shedding, Young Adult.
- MESH :
- chemical , blood : Antibodies, Neutralizing, Antibodies, Viral.
- immunology : Coronavirus Infections.
- isolation & purification : Middle East Respiratory Syndrome Coronavirus.
- virology : Blood, Coronavirus Infections, Feces, Respiratory System, Urine.
- Adult, Aged, Aged, 80 and over, Antibody Formation, Female, Humans, Male, Middle Aged, Virus Shedding, Young Adult.
Abstract
In a study of viral load, shedding, and immune response in 37 cases of Middle East respiratory syndrome coronavirus infection, virus was not eliminated upon development of neutralizing serum antibodies. Vaccination strategies should not be restricted to eliciting neutralizing antibodies.
Url:
DOI: 10.1093/cid/civ951
PubMed: 26565003
PubMed Central: 7108065
Affiliations:
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Le document en format XML
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Corman</name><affiliation><nlm:aff id="af1"><institution>Institute of Virology, University of Bonn Medical Centre</institution></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><institution>German Centre for Infection Research, Partner Site Bonn-Cologne</institution>,<addr-line>Bonn</addr-line>,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Albarrak, Ali M" sort="Albarrak, Ali M" uniqKey="Albarrak A" first="Ali M." last="Albarrak">Ali M. Albarrak</name><affiliation><nlm:aff id="af3"><addr-line>Division of Infectious Diseases</addr-line></nlm:aff></affiliation></author><author><name sortKey="Omrani, Ali Senosi" sort="Omrani, Ali Senosi" uniqKey="Omrani A" first="Ali Senosi" last="Omrani">Ali Senosi Omrani</name><affiliation><nlm:aff id="af3"><addr-line>Division of Infectious Diseases</addr-line></nlm:aff></affiliation></author><author><name sortKey="Albarrak, Mohammed M" sort="Albarrak, Mohammed M" uniqKey="Albarrak M" first="Mohammed M." last="Albarrak">Mohammed M. Albarrak</name><affiliation><nlm:aff id="af4"><addr-line>Department of Critical Care</addr-line></nlm:aff></affiliation></author><author><name sortKey="Farah, Mohamed Elamin" sort="Farah, Mohamed Elamin" uniqKey="Farah M" first="Mohamed Elamin" last="Farah">Mohamed Elamin Farah</name><affiliation><nlm:aff id="af5"><addr-line>Central Military Laboratory and Blood Bank, Microbiology Division</addr-line>,<institution>Prince Sultan Military City</institution></nlm:aff></affiliation></author><author><name sortKey="Almasri, Malak" sort="Almasri, Malak" uniqKey="Almasri M" first="Malak" last="Almasri">Malak Almasri</name><affiliation><nlm:aff id="af6"><institution>Ministry of Health</institution>,<addr-line>Riyadh</addr-line>,<country>Kingdom of Saudi Arabia</country></nlm:aff><wicri:noCountry code="nlm country">Kingdom of Saudi Arabia</wicri:noCountry></affiliation></author><author><name sortKey="Muth, Doreen" sort="Muth, Doreen" uniqKey="Muth D" first="Doreen" last="Muth">Doreen Muth</name><affiliation><nlm:aff id="af1"><institution>Institute of Virology, University of Bonn Medical Centre</institution></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><institution>German Centre for Infection Research, Partner Site Bonn-Cologne</institution>,<addr-line>Bonn</addr-line>,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sieberg, Andrea" sort="Sieberg, Andrea" uniqKey="Sieberg A" first="Andrea" last="Sieberg">Andrea Sieberg</name><affiliation><nlm:aff id="af1"><institution>Institute of Virology, University of Bonn Medical Centre</institution></nlm:aff></affiliation></author><author><name sortKey="Meyer, Benjamin" sort="Meyer, Benjamin" uniqKey="Meyer B" first="Benjamin" last="Meyer">Benjamin Meyer</name><affiliation><nlm:aff id="af1"><institution>Institute of Virology, University of Bonn Medical Centre</institution></nlm:aff></affiliation></author><author><name sortKey="Assiri, Abdullah M" sort="Assiri, Abdullah M" uniqKey="Assiri A" first="Abdullah M." last="Assiri">Abdullah M. Assiri</name><affiliation><nlm:aff id="af6"><institution>Ministry of Health</institution>,<addr-line>Riyadh</addr-line>,<country>Kingdom of Saudi Arabia</country></nlm:aff><wicri:noCountry code="nlm country">Kingdom of Saudi Arabia</wicri:noCountry></affiliation></author><author><name sortKey="Binger, Tabea" sort="Binger, Tabea" uniqKey="Binger T" first="Tabea" last="Binger">Tabea Binger</name><affiliation><nlm:aff id="af1"><institution>Institute of Virology, University of Bonn Medical Centre</institution></nlm:aff></affiliation></author><author><name sortKey="Steinhagen, Katja" sort="Steinhagen, Katja" uniqKey="Steinhagen K" first="Katja" last="Steinhagen">Katja Steinhagen</name><affiliation wicri:level="1"><nlm:aff id="af7"><institution>Euroimmun AG</institution>,<addr-line>Lübeck</addr-line>,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lattwein, Erik" sort="Lattwein, Erik" uniqKey="Lattwein E" first="Erik" last="Lattwein">Erik Lattwein</name><affiliation wicri:level="1"><nlm:aff id="af7"><institution>Euroimmun AG</institution>,<addr-line>Lübeck</addr-line>,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Al Tawfiq, Jaffar" sort="Al Tawfiq, Jaffar" uniqKey="Al Tawfiq J" first="Jaffar" last="Al-Tawfiq">Jaffar Al-Tawfiq</name><affiliation><nlm:aff id="af8"><institution>Johns Hopkins Aramco Healthcare</institution>,<addr-line>Dhahran</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af9"><institution>Indiana University School of Medicine</institution>,<addr-line>Indianapolis</addr-line></nlm:aff></affiliation></author><author><name sortKey="Muller, Marcel A" sort="Muller, Marcel A" uniqKey="Muller M" first="Marcel A." last="Müller">Marcel A. Müller</name><affiliation><nlm:aff id="af1"><institution>Institute of Virology, University of Bonn Medical Centre</institution></nlm:aff></affiliation></author><author><name sortKey="Drosten, Christian" sort="Drosten, Christian" uniqKey="Drosten C" first="Christian" last="Drosten">Christian Drosten</name><affiliation><nlm:aff id="af1"><institution>Institute of Virology, University of Bonn Medical Centre</institution></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><institution>German Centre for Infection Research, Partner Site Bonn-Cologne</institution>,<addr-line>Bonn</addr-line>,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Memish, Ziad A" sort="Memish, Ziad A" uniqKey="Memish Z" first="Ziad A." last="Memish">Ziad A. Memish</name><affiliation><nlm:aff id="af6"><institution>Ministry of Health</institution>,<addr-line>Riyadh</addr-line>,<country>Kingdom of Saudi Arabia</country></nlm:aff><wicri:noCountry code="nlm country">Kingdom of Saudi Arabia</wicri:noCountry></affiliation><affiliation><nlm:aff id="af10"><institution>College of Medicine, Alfaisal University</institution>,<addr-line>Riyadh</addr-line>,<country>Kingdom of Saudi Arabia</country></nlm:aff><wicri:noCountry code="nlm country">Kingdom of Saudi Arabia</wicri:noCountry></affiliation></author></analytic><series><title level="j">Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America</title><idno type="ISSN">1058-4838</idno><idno type="eISSN">1537-6591</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Antibodies, Neutralizing (blood)</term><term>Antibodies, Viral (blood)</term><term>Antibody Formation</term><term>Blood (virology)</term><term>Coronavirus Infections (immunology)</term><term>Coronavirus Infections (virology)</term><term>Feces (virology)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Middle East Respiratory Syndrome Coronavirus (isolation & purification)</term><term>Respiratory System (virology)</term><term>Urine (virology)</term><term>Virus Shedding</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Anticorps antiviraux (sang)</term><term>Anticorps neutralisants (sang)</term><term>Appareil respiratoire (virologie)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification)</term><term>Excrétion virale</term><term>Femelle</term><term>Fèces (virologie)</term><term>Humains</term><term>Infections à coronavirus (immunologie)</term><term>Infections à coronavirus (virologie)</term><term>Jeune adulte</term><term>Mâle</term><term>Production d'anticorps</term><term>Sang (virologie)</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Urine (virologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Neutralizing</term><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term><term>Anticorps neutralisants</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Appareil respiratoire</term><term>Fèces</term><term>Infections à coronavirus</term><term>Sang</term><term>Urine</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Blood</term><term>Coronavirus Infections</term><term>Feces</term><term>Respiratory System</term><term>Urine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Antibody Formation</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Virus Shedding</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Excrétion virale</term><term>Femelle</term><term>Humains</term><term>Jeune adulte</term><term>Mâle</term><term>Production d'anticorps</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>In a study of viral load, shedding, and immune response in 37 cases of Middle East respiratory syndrome coronavirus infection, virus was not eliminated upon development of neutralizing serum antibodies. Vaccination strategies should not be restricted to eliciting neutralizing antibodies.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zaki, Am" uniqKey="Zaki A">AM Zaki</name></author><author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S van Boheemen</name></author><author><name sortKey="Bestebroer, Tm" uniqKey="Bestebroer T">TM Bestebroer</name></author><author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name></author><author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Oboho, Ik" uniqKey="Oboho I">IK Oboho</name></author><author><name sortKey="Tomczyk, Sm" uniqKey="Tomczyk S">SM Tomczyk</name></author><author><name sortKey="Al Asmari, Am" uniqKey="Al Asmari A">AM Al-Asmari</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name></author><author><name sortKey="Muth, D" uniqKey="Muth D">D Muth</name></author><author><name sortKey="Corman, Vm" uniqKey="Corman V">VM Corman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cowling, Bj" uniqKey="Cowling B">BJ Cowling</name></author><author><name sortKey="Park, M" uniqKey="Park M">M Park</name></author><author><name sortKey="Fang, Vj" uniqKey="Fang V">VJ Fang</name></author><author><name sortKey="Wu, P" uniqKey="Wu P">P Wu</name></author><author><name sortKey="Leung, Gm" uniqKey="Leung G">GM Leung</name></author><author><name sortKey="Wu, Jt" uniqKey="Wu J">JT Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Poon, Ll" uniqKey="Poon L">LL Poon</name></author><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y Guan</name></author><author><name sortKey="Nicholls, Jm" uniqKey="Nicholls J">JM Nicholls</name></author><author><name sortKey="Yuen, 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Tsang</name></author><author><name sortKey="Tang, Cs" uniqKey="Tang C">CS Tang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leung, Wk" uniqKey="Leung W">WK Leung</name></author><author><name sortKey="To, Kf" uniqKey="To K">KF To</name></author><author><name sortKey="Chan, Pk" uniqKey="Chan P">PK Chan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Buchholz, U" uniqKey="Buchholz U">U Buchholz</name></author><author><name sortKey="Muller, Ma" uniqKey="Muller M">MA Muller</name></author><author><name sortKey="Nitsche, A" uniqKey="Nitsche A">A Nitsche</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li></country></list><tree><noCountry><name sortKey="Al Tawfiq, Jaffar" sort="Al Tawfiq, Jaffar" uniqKey="Al Tawfiq J" first="Jaffar" last="Al-Tawfiq">Jaffar Al-Tawfiq</name><name sortKey="Albarrak, Ali M" sort="Albarrak, Ali M" uniqKey="Albarrak A" first="Ali M." last="Albarrak">Ali M. Albarrak</name><name sortKey="Albarrak, Mohammed M" sort="Albarrak, Mohammed M" uniqKey="Albarrak M" first="Mohammed M." last="Albarrak">Mohammed M. Albarrak</name><name sortKey="Almasri, Malak" sort="Almasri, Malak" uniqKey="Almasri M" first="Malak" last="Almasri">Malak Almasri</name><name sortKey="Assiri, Abdullah M" sort="Assiri, Abdullah M" uniqKey="Assiri A" first="Abdullah M." last="Assiri">Abdullah M. Assiri</name><name sortKey="Binger, Tabea" sort="Binger, Tabea" uniqKey="Binger T" first="Tabea" last="Binger">Tabea Binger</name><name sortKey="Farah, Mohamed Elamin" sort="Farah, Mohamed Elamin" uniqKey="Farah M" first="Mohamed Elamin" last="Farah">Mohamed Elamin Farah</name><name sortKey="Memish, Ziad A" sort="Memish, Ziad A" uniqKey="Memish Z" first="Ziad A." last="Memish">Ziad A. Memish</name><name sortKey="Meyer, Benjamin" sort="Meyer, Benjamin" uniqKey="Meyer B" first="Benjamin" last="Meyer">Benjamin Meyer</name><name sortKey="Muller, Marcel A" sort="Muller, Marcel A" uniqKey="Muller M" first="Marcel A." last="Müller">Marcel A. Müller</name><name sortKey="Omrani, Ali Senosi" sort="Omrani, Ali Senosi" uniqKey="Omrani A" first="Ali Senosi" last="Omrani">Ali Senosi Omrani</name><name sortKey="Sieberg, Andrea" sort="Sieberg, Andrea" uniqKey="Sieberg A" first="Andrea" last="Sieberg">Andrea Sieberg</name></noCountry><country name="Allemagne"><noRegion><name sortKey="Corman, Victor M" sort="Corman, Victor M" uniqKey="Corman V" first="Victor M." last="Corman">Victor M. Corman</name></noRegion><name sortKey="Drosten, Christian" sort="Drosten, Christian" uniqKey="Drosten C" first="Christian" last="Drosten">Christian Drosten</name><name sortKey="Lattwein, Erik" sort="Lattwein, Erik" uniqKey="Lattwein E" first="Erik" last="Lattwein">Erik Lattwein</name><name sortKey="Muth, Doreen" sort="Muth, Doreen" uniqKey="Muth D" first="Doreen" last="Muth">Doreen Muth</name><name sortKey="Steinhagen, Katja" sort="Steinhagen, Katja" uniqKey="Steinhagen K" first="Katja" last="Steinhagen">Katja Steinhagen</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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